Nik Tsotakos, Ph.D.

Nik Tsotakos
Assistant Professor of Biology, School of Science, Engineering, and Technology
Office Phone
Office Location
Science & Engineering Building, TL170
8 a.m. - 5 p.m
Biography

Dr. Tsotakos comes to Penn State Harrisburg from Dickinson College, where he was a Visiting Assistant Professor of Biology. Before that, he was performing research at the Department of Pediatrics of Penn State College of Medicine in Hershey, PA, and in the Institute of Biology of the National Center for Scientific Research "Demokritos" near Athens, Greece. Dr. Tsotakos holds a B.Ss. in Biology from the Aristotle University of Thessaloniki (Greece), and a Ph.D. in Biological Chemistry from the National and Kapodistrian University of Athens (Greece)

Research Interests

Differential gene expression in health and disease

Gene Expression Regulation

Long non-coding RNAs

Publications

Tang Z, Takahashi Y, Chen C, Liu Y, He H, Tsotakos N, Serfass JM, Gebru MT, Chen H, Young MM, Wang HG. Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis. Cell Death Differ. 2017 Dec;24(12):2127-2138. doi: 10.1038/cdd.2017.133. Epub 2017 Aug 11. PubMed PMID: 28800131; PubMed Central PMCID: PMC5686350

Serfass JM, Takahashi Y, Zhou Z, Kawasawa YI, Liu Y, Tsotakos N, Young MM, Tang Z, Yang L, Atkinson JM, Chroneos ZC, Wang HG. Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. J Biol Chem. 2017 Jun 16;292(24):10097-10111. doi: 10.1074/jbc.M117.792747. Epub 2017 Apr 28. PubMed PMID: 28455444; PubMed Central PMCID: PMC5473216

Tsotakos N, Phelps DS, Yengo CM, Chinchilli VM, Floros J. Single-cell analysis reveals differential regulation of the alveolar macrophage actin cytoskeleton by surfactant proteins A1 and A2: implications of sex and aging. Biol Sex Differ. 2016 Mar 18;7:18. doi: 10.1186/s13293-016-0071-0. eCollection 2016. PubMed PMID: 26998217; PubMed Central PMCID: PMC4797174

Takahashi Y, Tsotakos N, Liu Y, Young MM, Serfass J, Tang Z, Abraham T, Wang HG. The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs. Oncotarget. 2016 Apr 12;7(15):20855-68. doi: 10.18632/oncotarget.8028. PubMed PMID: 26980706; PubMed Central PMCID: PMC4991497

Tsotakos N, Silveyra P, Lin Z, Thomas N, Vaid M, Floros J. Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L58-75. doi: 10.1152/ajplung.00058.2014. Epub 2014 Oct 17. PubMed PMID: 25326576; PubMed Central PMCID: PMC4281701

Silveyra P, Chroneos ZC, DiAngelo SL, Thomas NJ, Noutsios GT, Tsotakos N, Howrylak JA, Umstead TM, Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study. Exp Lung Res. 2014 Sep;40(7):354-66. doi: 10.3109/01902148.2014.929757. Epub 2014 Jul 24. PubMed PMID: 25058539; PubMed Central PMCID: PMC4197128

Tsotakos NE, Sagnou M, Kotsopoulou ES, Tsilibary EC, Drossopoulou GI. Glucose-induced gradual phenotypic modulation of cultured human glomerular epithelial cells may be independent of Wilms' tumor 1 (WT1). BMC Cell Biol. 2013 Jun 14;14:28. doi: 10.1186/1471-2121-14-28. PubMed PMID: 23768159; PubMed Central PMCID: PMC3686613

Drossopoulou GI, Tsotakos NE, Tsilibary EC. Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes. Am J Physiol Renal Physiol. 2009 Sep;297(3):F594-603. doi: 10.1152/ajprenal.00203.2009. Epub 2009 Jul 15. PubMed PMID: 19605546

Rabias I, Pratsinis H, Drossopoulou G, Fardis M, Maris T, Boukos N, Tsotakos N, Kletsas D, Tsilibary E, Papavassiliou G. In vitro studies on ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid for T2 MRI contrast agent. Biomicrofluidics. 2007 Nov 30;1(4):44104. doi: 10.1063/1.2821757. PubMed PMID: 19693403; PubMed Central PMCID: PMC2717733

Education

Ph.D. in Biological Chemistry (National Kapodistrian University of Athens)

B.Sc. in Biology (Aristotle University of Thessaloniki)